MTL devices are better used with PG-based E-Liquids,  as they provide a throat hit and usually work better with a high nic strength. Mouth-to-lung tanks use thinner e-liquids, like those comprised of 50% PG or higher percentages. This delivers a pleasant throat hit, as well as a very enjoyable flavour.

DTL (Drirect To Lung or most commonly known as Sub-Ohm) devices are better used with VG-based E-Liquids, as they are much thicker than PG based liquids, and more intense than MTL. They are also best used with a lower nicotine strength, increasing the flavour production. Direct-To-Lung tanks use thicker e-liquids, like those comprised of 60% VG or higher percentages. This delivers a lower throat hit, as well as an enhanced flavour.